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275,322 M1 macrophages promote immune activation and contribute to tissue injury by producing nitric oxide, ROS, various chemokines (CXCL2, CXCL4, and CCL5), and proinflammatory cytokines such as TNF-α, IL-1β, and IL-6

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The accepted treatment is daily intramuscular injections of vitamin B12 and supplemental oral betaine.9,13 MAT The MAT enzyme controls the transfer of an adenosyl group from ATP to methionine to form SAM, the first step in the methionine cycle